The main goal of the Giraldez Laboratory is to understand the cellular and molecular signals that initiate embryonic development to uncover universal principles that direct the development of a new life.
A universal step in all animals is the maternal to zygotic transition, whereby the transcriptionally silent egg activates the new zygotic program and removes the old maternal program. This central step in animal development can be considered the beginning of life from a transcriptional standpoint, whereby subsequent developmental decisions will depend on the correct activation of the zygotic program and regulation of the previous maternal program.
The questions: How the vertebrate embryo activate the silent zygotic genome? How does the embryo regulate the previous developmental program? How do the building blocks in the genome, coding and non-coding elements, orchestrate these processes?
The approaches: We have a multidisciplinary infrastructure (wet/dry) that allows us to combine genomics, embryology, biochemistry and computational biology to leverage the powerful genetics in zebrafish to understand vertebrate development.
Research Area: Computational Biology, Single-cell Sequencing, Functional Genomics, and Machine learning to understand the mechanisms of gene regulation.
The Giraldez lab combines genomics, computational biology and genetics to identify fundamental processes in biology, gene regulation and developmental biology. We have a strong interest in understanding the molecular mechanisms of cellular transitions in vertebrates using zebrafish and other model systems. Our lab has several computational biologists integrated with experimentalists, providing a wonderful interdisciplinary background and cross training in wet biology.
Projects: Several projects are available for a computational biologist to undertake either of the following projects: 1) single-cell sequencing analysis to understand the regulatory code of cell fate specification, or 2) utilization of computational tools to model gene expression and translation integrating the signals from multiple regulatory mechanisms that we have discovered in the lab. I also encourage creative postdocs to develop new areas of research including gene regulatory networks, chromatin regulation, single-cell gene expression analysis, translational regulation, RNA-protein interaction networks and RNA structure in vertebrate development.
Qualifications: Applicants require a strong background in computational biology, Python, Perl, R and machine learning. Only applicants with this expertise will be considered for this position. Experience in molecular biology or developmental biology is not necessary.
Application: Please send your application as a PDF file including a CV, summary and relevance of your current research (500 word max), why you are interested in the Giraldez lab (200 word max) and names of three references to: antonio.giraldez@yale.edu . Include “Computational Biology 2022” in the subject of the email. Only application that provide these materials will be considered. Applications will be considered as they arrive, until the positions are filled.
The Giraldez laboratory at Yale University is looking to fill a position for a Postdoctoral Fellow in Research Development and Science Communication. This is a unique opportunity to train in the field of academic research development, scientific strategy, and grant-writing. The position will provide key strategic support to further the directions, funding, and impact of the lab’s research on mechanisms of gene regulation in early embryonic development.
About you: We seek an individual with a PhD in the life sciences who is motivated, reliable, flexible, and who can work both independently and within a team. Knowledge and experience in developmental biology, genomics, epigenetics and/or chromatin biology is required as well as excellent writing, editing, communication, and organizational skills. The successful applicant will thrive in the scientific, cultural, and intellectual diversity that fosters a strong sense of collegiality and community in the Giraldez lab and the Department of Genetics generally.
About the role: The successful applicant will be fully integrated in the Giraldez lab and will report directly to Prof. Antonio Giraldez. The primary responsibilities of the role are:
• To work with other trainees, staff, and faculty in the preparation of new and ongoing investigator-led funding proposals
• To work with other trainees, staff, and faculty in the preparation of new and ongoing manuscript submissions
• To provide strategic advice regarding individual research directions and emerging research projects
The successful applicant will interface with the Office for Strategic Research Development (ORSD) in the Department of Genetics for ongoing training, mentorship, and professional development. Under the leadership of the Scientific Director and Advisor to the Chair, ORSD provides strategic support to faculty across a range of initiatives designed to support their scientific and professional growth.
About us: The successful applicant will join a vibrant community of exceptional scientists who recognize the fundamental importance of diversity as a key driver of innovation in science. The Giraldez lab is rich in thoughts and ideas and driven by curiosity, passion, and the pursuit of scientific discovery. Our lab members are open, collegial, and committed to supporting each other’s scientific and professional growth.
Qualifications: Candidates should hold a PhD in one of the life sciences and good working knowledge across developmental biology, genomics, epigenetics and/or chromatin biology. Candidates must have outstanding written communication skills and be highly organized with the demonstrated ability to prioritize, plan, multi-task, and meet deadlines. Prior experience in writing and/or editorial is not required however will be considered favorably.
Application Instructions: Applicants interested in this position must apply via the following link: https://apply.interfolio.com/108859. Applications will be considered on a rolling basis until the position is filled. Applications should contain a cover letter describing your motivation for the position and relevant experience, your CV, a short, easily digestible summary of a recent paper of interest, and the contact information of three individuals to provide letters of recommendation to the attention of Professor Antonio Giraldez. Applicants will also be required to answer a set of questions pertaining to diversity and inclusion in Interfolio. All inquiries should be addressed to antonio.giraldez@yale.edu
The Department of Genetics is dedicated to providing an inclusive workplace that promotes and values diversity in age, gender identity, race, sexual orientation, physical or mental ability, and ethnicity. Please refer to the official Yale University statement on diversity and inclusion, accessible here: https://medicine.yale.edu/diversity/
The Giraldez laboratory at Yale University is seeking to recruit a highly qualified Associate Research Scientist as a long-term scientist in the laboratory. Prerequisites for appointment on the research scientist track include a doctoral degree and relevant postdoctoral experience.
The successful candidate will be a highly-motivated scientist with excellent organizational, mentoring and leadership skills. They will be responsible for coordinating the overall scientific operations of the Giraldez lab and will provide critical training and mentoring to individual lab members. In addition, the successful candidate will have the opportunity to participate in multiple research projects and drive a scientific project aligned with the major interests of the laboratory. The successful candidate will have the following attributes:
· A doctoral degree and relevant postdoctoral experience
· Excellent interpersonal and communication skills
· Excellent organizational skills and attention to detail
· Solid publication record and the ability to drive long-term, successful research projects
· Expertise in one or more of the following: molecular biology, chromatin biology, developmental biology, genomics, and/or imaging
This appointment can be renewed indefinitely provided the need for the position continues, the funding for the position is available, and the expectations for performance are met.
Yale University is an Affirmative Action/Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.
To apply to this position please prepare the following documents.
Applications should be submitted by email to sarah.dube@yale.edu. Please include “Associate Research Scientist” in the subject of the email.
The Giraldez Lab is part of the Yale Combined Program in the Biological and Biomedical Sciences (BBS). Interested students should send Antonio an e-mail to arrange a meeting.