Developmental Biology: Post-doctoral positions

Developmental Biologist

Research Area: The maternal to zygotic transition

Project title: Regulatory networks that control early embryonic development, maternal mRNA decay and zygotic genome activation

Description of project: A postdoctoral position is available to understand the regulatory interactions that control maternal mRNA decay and zygotic genome activation using CRISPR-Cas9 genetic screening

Applicants require a strong background in genetics and developmental biology using a model system.

Please e-mail CV, summary and relevance of your current research (500 word max), why you are interested in the giraldez lab (200 word max) and names of three references to:
Please include the title “Developmental Biology, Postdoctoral Position” in the subject of the e-mail

These are some of the papers recently published by the laboratory:

  1. 1.Hoffman EJ, Turner KJ, Fernandez JM, Cifuentes D, Ghosh M, Ijaz S, Jain RA, Kubo F, Bill BR, Baier H, Granato M, Barresi MJ, Wilson SW, Rihel J, State MW, Giraldez AJ. Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2. Neuron. 2016 Feb 17;89(4):725-33. doi: 10.1016/j.neuron.2015.12.039. Epub 2016 Jan 28.

  2. 2.Johnstone TG, Bazzini AA, Giraldez AJ. Upstream ORFs are prevalent translational repressors in vertebrates. EMBO J. 2016 Feb 19. pii: e201592759.

  3. 3.Moreno-Mateos MA, Vejnar CE, Beaudoin JD, Fernandez JP, Mis EK, Khokha MK and Giraldez AJ‡. CRISPRscan: designing highly efficient sgRNAs for CRISPR/Cas9 targeting in vivo. Nature Methods. 2015.

  4. 4.Bazzini AA, Johnstone TG, Christiano R, Mackowiak SD, Obermayer B, Fleming ES, Vejnar CE, Lee MT, Rajewsky N, Walther TC, Giraldez AJ. Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation.EMBO J. 2014 May 2;33(9):981-93.

  5. 5.Lee MT*, Bonneau AR*, Takacs CM, Bazzini AA, Divito KR, Fleming ES, Giraldez AJ Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition. Nature. 2013 Sep 22. 

  6. 6.Bazzini AA, Lee MT, Giraldez AJ‡. Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish. Science 13 April 2012: 233-237.

  7. 7.Cifuentes D, Xue H, Taylor DW, Patnode H, Mishima Y, Cheloufi S, Ma E, Mane S, Hannon GJ, Lawson N, Wolfe S, Giraldez AJ‡. A novel miRNA processing pathway independent of Dicer requires Argonaute2. Science. 2010, Jun 25

  8. 8.Giraldez AJ‡, Mishima Y, Rihel J, Grocock R, van Dongen S, Inoue, K, Enright A, and Schier AF‡. Zebrafish miR-430 promotes deadenylation and clearance of maternal mRNAs. Science. 2006 Apr 7