Autism and human disease: Post-doctoral positions
New
HavenDirections/Directions.html
 

Autism and human disease

Research Area: Analysis of autism causing mutations in zebrafish

Description of project: A postdoctoral position is available to dissect the molecular mechanisms that cause autism. The goals are to identify autism causing mutations in humans and  1) engineer them in zebrafish, then, 2) identify the neurodevelopmental, behavioral, and electro physiological phenotypes. Once the phenotypes are identified, we will use chemical behavioral profiling to identify small molecules that suppress the identified phenotypes. The ultimate goal is to define small molecules that could eventually suppress neurodevelopmental defects in autism.

Applicants require a strong background in developmental neurobiology using a model system.


Please e-mail CV, summary and relevance of your current research (500 word max), why you are interested in the giraldez lab (200 word max) and names of three references to: giraldezlab@gmail.com
Please include the title “Autism and human disease, Postdoctoral Position” in the subject of the e-mail


These are some of the papers recently published by the laboratory relevant to this topic:

  1. 1.Hoffman EJ, Turner KJ, Fernandez JM, Cifuentes D, Ghosh M, Ijaz S, Jain RA, Kubo F, Bill BR, Baier H, Granato M, Barresi MJ, Wilson SW, Rihel J, State MW, Giraldez AJ. Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2. Neuron. 2016 Feb 17;89(4):725-33. doi: 10.1016/j.neuron.2015.12.039. Epub 2016 Jan 28.

  2. 2.Moreno-Mateos MA, Vejnar CE, Beaudoin JD, Fernandez JP, Mis EK, Khokha MK and Giraldez AJ‡. CRISPRscan: designing highly efficient sgRNAs for CRISPR/Cas9 targeting in vivo. Nature Methods. 2015.

  3. 3.Takacs CM, Giraldez AJ. miR-430 regulates oriented cell division during neural tube development in zebrafish. Dev Biol. 2016 Jan 15;409(2):442-50. doi: 10.1016/j.ydbio.2015.11.016. Epub 2015 Nov 30.